Ipamorelin vs CJC-1295
Ipamorelin and CJC-1295 are the classic growth-hormone research pair. They act on two different parts of the GH axis, which is exactly why they are so often combined rather than compared as substitutes.
| Ipamorelin | CJC-1295 (no DAC) | |
|---|---|---|
| Compound class | Selective GHRP (ghrelin-receptor agonist) | GHRH analog (mod GRF 1-29) |
| Primary target | GHS-R (ghrelin receptor) | GHRH receptor |
| Category | Growth Hormone | Growth Hormone |
| Administration | Subcutaneous, 1-3x daily | Subcutaneous, 1-3x daily |
| Research focus | Clean GH pulse, minimal cortisol/prolactin | Amplified GH pulse amplitude |
Key differences
- Mechanism: ipamorelin is a GHRP (ghrelin-receptor agonist) that triggers a GH pulse; CJC-1295 (no DAC) is a GHRH analog that amplifies pulse amplitude.
- Selectivity: ipamorelin is prized for a clean pulse with minimal cortisol or prolactin; CJC-1295 increases how much GH each pulse releases.
- Synergy: combined, a GHRP plus a GHRH analog produce a larger, more physiological pulse than either alone — the basis of the popular blend.
- Both are subcutaneous and dosed one to three times daily around the same windows.
Which is right for your research?
These are partners, not rivals. Ipamorelin initiates a clean pulse; CJC-1295 makes that pulse bigger. Most GH research protocols run them together.
Frequently asked questions
What is the difference between ipamorelin and CJC-1295?
Ipamorelin is a GHRP that triggers a GH pulse, while CJC-1295 is a GHRH analog that amplifies the size of that pulse. They act on different receptors.
Why are ipamorelin and CJC-1295 used together?
Combining a GHRP with a GHRH analog produces a larger, more physiological GH pulse than either compound alone, which is why they are commonly stacked.
Does ipamorelin cause cortisol or prolactin increases?
Ipamorelin is valued for being selective, producing a clean GH pulse with minimal cortisol or prolactin in research models.
For Research Use Only. All products are sold as research chemicals for in-vitro laboratory study. Not for human consumption, medical, veterinary, or household use.