MOTS-c vs 5-Amino-1MQ
Both are studied for metabolism, but they could not be more different structurally. MOTS-c is an injectable mitochondrial-derived peptide; 5-Amino-1MQ is an oral small-molecule enzyme inhibitor.
| MOTS-c | 5-Amino-1MQ | |
|---|---|---|
| Compound class | Mitochondrial-derived peptide | Small-molecule NNMT inhibitor |
| Primary target | AMPK / metabolic signaling | Nicotinamide N-methyltransferase (NNMT) |
| Category | Anti-Aging & Longevity | GLP-1 & Metabolic |
| Administration | Subcutaneous | Oral, daily |
| Research focus | Mitochondrial function & metabolic flexibility | Adipocyte energy metabolism |
Key differences
- Mechanism: MOTS-c signals through AMPK and mitochondrial pathways; 5-Amino-1MQ inhibits the NNMT enzyme in adipocytes.
- Route: MOTS-c is injected subcutaneously; 5-Amino-1MQ is taken orally.
- Research focus: MOTS-c is studied for metabolic flexibility and mitochondrial function; 5-Amino-1MQ for adipocyte energy metabolism.
- Format: peptide vs small molecule — different stability, handling, and storage considerations.
Which is right for your research?
Choose MOTS-c for mitochondrial and exercise-mimetic research, and 5-Amino-1MQ when an oral NNMT-inhibition mechanism fits the study design.
Frequently asked questions
Is 5-Amino-1MQ a peptide like MOTS-c?
No. MOTS-c is a mitochondrial-derived peptide, while 5-Amino-1MQ is a small-molecule NNMT inhibitor.
How is each administered?
MOTS-c is injected subcutaneously; 5-Amino-1MQ is taken orally.
What mechanism does each use?
MOTS-c works through AMPK and mitochondrial signaling; 5-Amino-1MQ inhibits the NNMT enzyme involved in adipocyte metabolism.
For Research Use Only. All products are sold as research chemicals for in-vitro laboratory study. Not for human consumption, medical, veterinary, or household use.