MOTS-c vs SS-31
MOTS-c and SS-31 are both mitochondrial peptides, which makes them natural rivals in bioenergetics research. The distinction is where they act: MOTS-c signals metabolic pathways, while SS-31 binds cardiolipin directly inside the mitochondrial membrane.
| MOTS-c | SS-31 (Elamipretide) | |
|---|---|---|
| Compound class | Mitochondrial-derived peptide | Mitochondria-targeted tetrapeptide |
| Primary target | AMPK / metabolic signaling | Cardiolipin (inner mitochondrial membrane) |
| Category | Anti-Aging & Longevity | Anti-Aging & Longevity |
| Administration | Subcutaneous | Subcutaneous |
| Research focus | Mitochondrial function & metabolic flexibility | Mitochondrial bioenergetics & protection |
Key differences
- Mechanism: MOTS-c is a mitochondrial-derived peptide signaling through AMPK; SS-31 (Elamipretide) targets cardiolipin in the inner mitochondrial membrane to protect bioenergetics.
- Research focus: MOTS-c for metabolic flexibility and exercise-mimetic endpoints; SS-31 for mitochondrial protection and energy output.
- Site of action: signaling/metabolic (MOTS-c) vs structural/membrane (SS-31).
- Both are subcutaneous peptides used in longevity and mitochondrial research.
Which is right for your research?
MOTS-c is the metabolic-signaling mitochondrial peptide; SS-31 is the membrane-protective one. They complement different aspects of mitochondrial research.
Frequently asked questions
Are MOTS-c and SS-31 both mitochondrial peptides?
Yes, but they act differently. MOTS-c signals through AMPK and metabolic pathways, while SS-31 binds cardiolipin in the inner mitochondrial membrane.
What is SS-31 also called?
SS-31 is also known as Elamipretide.
Which is more about metabolism?
MOTS-c is the more metabolically focused peptide; SS-31 emphasizes mitochondrial membrane protection and bioenergetics.
For Research Use Only. All products are sold as research chemicals for in-vitro laboratory study. Not for human consumption, medical, veterinary, or household use.